TDP-43 imaging tracers
Two candidate TDP-43 imaging tracers were tested in human tissue and model systems. They bound to pathological TDP-43 in several disease subtypes but not in controls, hinting at a future biological diagnosis. The lead tracer, ACI-19626, showed better brain uptake and specificity and is headed to a first-in-human trial, though broader studies are needed to confirm general usefulness.
Research#Amyotrophic Lateral Sclerosis (ALS)#Motor Neurone Disease (MND)#TDP-43